Takinoue Lab

Bio-inspired Systems Physics

Our group studies the construction of bio-inspired dynamical self-organized systems (molecular robots, artificial cells) using information molecules such as DNA. Through their construction, we are challenging to understand “What is Life?” from a physical point of view about nano/micro-scale autonomous systems and to invent novel post-silicon computing-based intelligent molecular machines, molecular computers, and molecular robots with sophisticated functions beyond life systems. [Japanese page]

Keywords: Molecular robotics; DNA molecular computing; Artificial cell engineering; Microfluidics; Molecular computer science; Biophysics of programmable soft matter; Nonequilibrium science; Post-silicon biocomputing.


[Recent work]

DNA-based artificial cytoskeleton for artificial cell-like systems:

  1. “DNA cytoskeleton for stabilizing artificial cells”, Proc. Natl. Acad. Sci. USA (PNAS), online, (2017). doi: 10.1073/pnas.1702208114. link
    Press release: [English]

Non-equilibrium artificial cell-like reactors based on droplet microfluidics:

  1. “Pulse-density modulation control of chemical oscillation far from equilibrium in a droplet open-reactor system”, Nature Commun. (2016). link
    Press release: [English]
  2. “A Bacterial Continuous Culture System Based on a Microfluidic Droplet Open Reactor”, Anal. Sci. (2016). link
    (awarded ‘Hot Article Award’ of this issue: link)

Centrifugal microfluidics for soft matter (microgels, droplets, artificial cells)

  1. Shoya Yasuda, Masayuki Hayakawa, Hiroaki Onoe, *Masahiro Takinoue, “Twisting microfluidics in a planetary centrifuge”, Soft Matter, 13(11), 2141-2147 (2017). doi:10.1039/C6SM02695H. link
    (highlighted as the front cover picture of the issue: link)
  2. “Droplet-Shooting and Size-Filtration (DSSF) Method for Synthesis of Cell-Sized Liposomes with Controlled Lipid Compositions”, ChemBioChem (2015). link
  3. “Generation of Monodisperse Cell-Sized Microdroplets using a Centrifuge-Based Axisymmetric Co-Flowing Microfluidic Device”, J. Biosci. Bioeng. (2015).  link
  4. “Complex-shaped three- dimensional multi-compartmental microparticles generated by diffusional and Marangoni microflows in centrifugally discharged droplets”, Sci. Rep. (2016). link
  5. Introduction in ‘Atlas of Science’: link

Publication List

For students

Message For Foreign Students
Lab Photo Gallery (Japanese)
Lab Member List


takinoue (at) c.titech.ac.jp
masahiro.takinoue (at) takinoue-lab.jp

Takinoue’s profile