Takinoue Lab

@(1) Dept. Computer Sci., (2) Dept. Life Sci. and Tech., and (3) Dept. Systems and Control Eng., Tokyo Tech

Bio-inspired Systems Physics

Our group studies the construction of bio-inspired molecular systems (molecular robots, molecular computersnanomachinesartificial cells, artificial nuclei) using DNA, proteins, microdroplets, vesicles, and microfluidic devices based on wet experiments and computer simulations. Through the construction, we are challenging to understand “What is Life?” from a physical point of view and to invent novel intelligent molecular systems with sophisticated functions beyond life. [Japanese page]

Keywords: Molecular robotics; DNA molecular computing; Artificial cell engineering; Microfluidics; Molecular computer science; Biophysics of programmable soft matter; Nonequilibrium science; Post-silicon biocomputing.

research_en

[Admission]

Students can join our lab as a master course student or a Ph.D. course student of Department of Computer Science, Department of Life Science and Technology, or Department of Systems and Control Engineering.

[News]

  • Labs spotlight in Department of Life Science and Technology – Takinoue Laboratory – [JP/EN]
  • Newsletter of Department of Life Science and Technology [JP/EN]

[Recent work]

DNA-based artificial cytoskeleton for artificial cell-like systems:

  1. “DNA cytoskeleton for stabilizing artificial cells”, Proc. Natl. Acad. Sci. USA (PNAS), online, (2017). doi: 10.1073/pnas.1702208114. link
    Press release: [English]

Non-equilibrium artificial cell-like reactors based on droplet microfluidics:

  1. “Pulse-density modulation control of chemical oscillation far from equilibrium in a droplet open-reactor system”, Nature Commun. (2016). link
    Press release: [English]
  2. “A Bacterial Continuous Culture System Based on a Microfluidic Droplet Open Reactor”, Anal. Sci. (2016). link
    (awarded ‘Hot Article Award’ of this issue: link)

Centrifugal microfluidics for soft matter (microgels, droplets, artificial cells)

  1. Shoya Yasuda, Masayuki Hayakawa, Hiroaki Onoe, *Masahiro Takinoue, “Twisting microfluidics in a planetary centrifuge”, Soft Matter, 13(11), 2141-2147 (2017). doi:10.1039/C6SM02695H. link
    (highlighted as the front cover picture of the issue: link)
  2. “Droplet-Shooting and Size-Filtration (DSSF) Method for Synthesis of Cell-Sized Liposomes with Controlled Lipid Compositions”, ChemBioChem (2015). link
  3. “Generation of Monodisperse Cell-Sized Microdroplets using a Centrifuge-Based Axisymmetric Co-Flowing Microfluidic Device”, J. Biosci. Bioeng. (2015).  link
  4. “Complex-shaped three- dimensional multi-compartmental microparticles generated by diffusional and Marangoni microflows in centrifugally discharged droplets”, Sci. Rep. (2016). link
  5. Introduction in ‘Atlas of Science’: link

Research
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 Contact

E-mail:
takinoue (at) c.titech.ac.jp
masahiro.takinoue (at) takinoue-lab.jp

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